White Paper: Lentiviral and Adeno-Associated Virus Gene Therapies

Current approaches to characterizing lentiviral and AAV-mediated gene therapies may miss insertional mutagenesis and correlated gene expression changes. Read our perspective on how emerging single-cell multiomics technologies put more comprehensive data in researchers' hands.

In this white paper, you'll read about:

• How characterizing transgene insertion and expression can improve cell and gene therapy development
• The deleterious effects of genomic and transcriptomic changes possible as a result of insertional mutagenesis
• Why single-cell multiomic analysis is necessary to characterize and validate viral gene therapy candidates
• Tools that make it possible to precisely, sensitively detect insertions, deletions, substitutions, larger genomic alterations, alternative splicing events, and altered gene expression across the entire genome – and attribute these variants to individual cells.