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Publications

A droplet-based microfluidic platform combined with primary template-directed amplification (PTA) enables the analysis of clonal heterogeneity and mosaicism in leukemia at single-cell genome level

Nan Zong

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Accurate detection of small genomic variants, copy number alterations, and heteroplasmy in early human embryos.
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Accurate Genomic Variant Detection in Single Cells with Primary Template-Directed Amplification
Adaptation of MAS-Seq/PacBio and ONT long read technology to the ResolveOME™ multiomic workflow for single-cell transcript isoform and DNA amplicon interrogation

Victor J. Weigman

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid
Broadening the input application of ResolveDNA genomic amplification to detection of SNV in circulating DNA

Jon S. Zawistowski

Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain
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Charting and deconvolution of microbial diversity by high-quality single-cell genomic reconstruction utilizing ResolveDNA Microbiome

Isai Salas González

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Co-delineating genomic and transcriptomic modes of resistance to MEK inhibition in individual triple negative breast cancer cells

D.M. Arvapalli

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Combined ResolveDNA® whole genome amplification with Twist Human Core Exome panel to generate high-quality human whole-exome data from single cells

Swetha D. Velivela

Comprehensive profiling of L1 retrotransposons in mouse
Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain
Defining ancestry, heritability and plasticity of 2 cellular phenotypes in somatic evolution
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Distinct resistance modalities to targeted kinase inhibition exposed by single-cell Primary Template-directed Amplification in acute myeloid leukemia and triple-negative breast cancer.
eBook: Cell and Gene Therapies
Elucidation Of Tumor Clonal Diversity in An AML Drug Resistance Model Using A High Throughput Single Cell Genome Amplification Method

S. Velivela

Enrichment of viable cells from patient samples with LeviCell technology as input into the ResolveOME single cell multiomic workflow

Alison Rojas

Exome, IcWGS-based copy number assessment, complete transcriptome & surface protein expression from the same individual cell with ResolveOME®

Katherine A. Kennedy

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Exploring drug resistance mechanisms in different drug resistance models of an AML cell line using ResolveOME™ combined genomics and transcriptomics chemistry

S.D. Velivela

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Exploring microbial biodiversity through genome analysis using ResolveDNA Microbiome

Durga M. Arvapalli

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Extracellular protein monitoring in the ResolveOMETM genomic and transcriptomic dual workflow to uncover cancer pathology mechanisms in single cells

T.V. Morozova

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Genome-Wide Disease Screening in Early Human Embryos with Primary Template-Directed Amplification
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Going beyond the atlas – mapping the tumor landscape with complete genomic signatures

Katherine Kennedy

High-fidelity, Large-scale Targeted Profiling of Microsatellites
High-Quality Nuclei Isolation from Postmortem Human Heart Muscle Tissues for Single-Cell Studies
Identification of a novel mosaic MTOR variant in purified neuronal DNA from depth electrodes in a patient with focal cortical dysplasia
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Improving the sensitivity of detection of low frequency somatic variants via Primary Template-directed Amplification of single cells.
Integration of scHi-C and scRNA-seq data defines distinct 3D-regulated and biological-context dependent cell subpopulations
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Integration of the ResolveOME™ multi-omics workflow with IDT xGen™ hybridization capture at single-cell resolution to obtain high quality exome data

Durga M. Arvapalli

Inter- and intratumoral PIK3CA subclonal diversity in breast cancer contextualized by single-cell multiomics

Jon S. Zawistowski1

Multiomic Single Cell Analysis of Primary Pancreatic Ductal Adenocarcinoma Enhanced by Fixation

Will Hwang

Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy
Quantitative characterization of on-target and off-target variation induced by CRISPR+Cas9 systems at the single-cell resolution

Isai Salas-Gonzalez

Realtime morphological characterization and sorting of unlabeled viable cells using deep learning
ResolveOME™ and ResolveDNA® Data Preprocessing with Fastp Using the Cloud-based BaseJumper™ Platform
scMicrobe PTA: Near Complete Genomes from Single Bacterial Cells
Single Day Workflow for High-Quality Whole Genome Analysis of Thousands of Single Cells with ResolveDNA

Jay A. West

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Single-cell clarity and heterogeneity in copy number profiles in primary synovial & Ewing sarcoma with ResolveDNA™ genomic amplification

Katherine A. Kennedy

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Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
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Single-cell identity and state coupled with genome-wide SNV and CNV in primary breast cancer with ResolveOME™ profiling

J.S. Zawistowski

Single-cell transcriptomic and genomic changes in the aging human brain
Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia
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Somatic genomic changes in single Alzheimer’s disease neurons
Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations
Somatic mutations reveal hypermutable brains and are associated with neuropsychiatric disorders
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The BaseJumper™ research platform for single cell multiomic analysis & interactive visualization

V. Weigman

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The ResolveOME™ platform: integrated whole genome and whole transcriptome profiling from a single cell to unlock drug resistance mechanisms

Tatiana V. Morozova

Trimodal Molecular Analysis in Single Cells of a Primary Breast Cancer Cohort with ResolveOME Amplification

Jon S. Zawistowski

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Ultraspecific somatic SNV and indel detection in single neurons using primary template-directed amplification
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Unbiased linkage of SNV to expression in single cells for regulatory variant discovery influencing cancer drug resistance

I. Salas-González

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Unifying genomics and transcriptomics in single cells to illuminate cancer...
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Unifying genomics and transcriptomics in single cells with ResolveOME™ amplification chemistry to illuminate oncogenic and drug resistance mechanisms
Unveiling Inter- and Intra-Tumor Heterogeneity in Ductal Carcinoma in Situ (DCIS) and Invasive Ductal Carcinoma (IDC) through Integration of Unified Single-Cell Copy Number and RNA Expression Data

Tia A. Tate

Validation of the first PGT-whole genome sequencing approach including mitochondrial variants
White Paper: CRISPR/Cas9 Gene Editing
White Paper: iPSC Therapies
White Paper: Viral Gene Therapies

Support

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A Fully Integrated Workflow Based on ResolveDNA® WGA for Complete Analysis of Human Embryos for Aneuploidy and Monogenic Disease (PGT-A + M)
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Accurate Single-cell Genomic Analysis Holds the Key to Understanding Cancer Heterogeneity
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Analysis of Somatic SNV and Indels in Single Neurons using ResolveDNA Whole Genome Amplification
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Assessing the Heterogeneity of Single Cancer Cells using Primary Template directed Amplification (PTA)
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BaseJumper FAQs
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BaseJumper™ Docs
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Contact us for WGA, library preparation, and cell sorting protocols
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Enrichment Workflows for Single Cell Genome Analysis
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Genomic Analysis of Single Bacteria using ResolveDNA® Microbiome
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Integrated Workflow for Spatial Single Cell Genome Analysis
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Integrated Workflows for Single Cell Genome Analysis
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Pairing Uniform Whole-Genome Amplification with Simple Single-cell Sorting
Resolve Training
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ResolveDNA® in primary breast cancer
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ResolveDNA® Interactive Tech Note
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ResolveDNA® Lysis Optimization
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ResolveDNA® WGA Testing Checklist
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ResolveDNA® Whole Genome Amplification v2.0
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ResolveOME™: Comprehensive Multi-omic Single-Cell Analysis
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Single Cell Exome
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Single-cell Isolation and Enrichment
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The BaseJumper™ Bioinformatics Platform

Videos

A multiomic, single-cell lens on clonal evolution in breast cancer (2023 AACR Presentation highlights)
AMP 2023: Discover Tumor Heterogeneity with Integrated Single-Cell Genomics and Transcriptomics
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ASHG: Primary Template-directed Amplification
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BaseJumper™
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BaseJumper™ Demo
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BioSkryb Genomics Webinar Single Cell Multiomic Analysis in AML
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Discover the difference BioSkryb Genomics can make for you in WGA
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Discover the “Why” behind BioSkryb Genomics
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Get to know BioSkryb first hand
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Harnessing Biotechnological Innovation for Pediatric Cancer
Leveraging single-cell whole genome sequencing to identify CRISPR/Cas9 gene editing on- and off-target events
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Resolve cancer heterogeneity with single-cell resolution
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ResolveOME™
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SFAF: Studying Cellular Evolution with Primary Template-directed Amplification (PTA)
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Toward Personalized High-Resolution Leukemia Treatments Strategies using Single-Cell Genomics